JOURNAL of the Tunisian Chemical Society

In the last few years, hair analysis has become an important alternative and complement to blood and urine analysis. The principal advantage of this matrix lies in its stability and the possibility of long-term detection. The purpose of this work was to compare the results of urine and hair analysis in a smoking cessation program study, and to develop a routine analytical procedure for the quantification of the two organic biological markers: nicotine (alkaloid of tobacco) and cotinine (its principal metabolite). The techniques used were gas and liquid chromatography coupled with mass spectrometry detector, The main results were concerning the influence of sampling and nicotine-metabolism on the urine analysis, and also the precious additional information gave by hair analysis.

I.E. Hassen, M.M. Flament-Waton, O. Paisse, M.F. Grenier Loustalot, H. Zarrouk

urine, hair, nicotine, cotinine, smoking cessation

Pages 209-220