JOURNAL of the Tunisian Chemical Society

An example of 1,3-dipolar cycloaddition reactions of arylnitrile oxide to pyrazolo[1,5-a]pyrimidines was described. The nitrile oxide reacts with the C3 –C4 double bond of pyrazolo[1,5-a]pyrimidine to give the corresponding pyrazolo[1,5-a]pyrimidine -isoxazolidines in moderate yields. The mechanism was discussed and the structure of all compounds was studied by IR and NMR Spectroscopy (¹H, ¹³C, ¹⁹F). Compound 4e was characterized by HRMS.

K. Bokri, I. Jalloul, M.L. Efrit, A. Ben Akacha

3,5-diaminopyrazole, pyrazolo[1,5-a]pyrimidine, 1,3-dipolar cycloaddition and arylnitrile oxide

Pages: 9-15